From sequence
design to
expression-ready DNA
in <24 hours
Turn AI-designed sequences into ready-to-express DNA with intelligent, on-premises synthesis. Gibson SOLA® closes the loop from design to biological data – allowing iteration up to 10x faster.
THE INTEGRATED WORKFLOW
One integrated solution from design to DNA
The Gibson SOLA platform seamlessly integrates into your AI infrastructure to evaluate and optimize hypothesized sequences. Intelligent Synthesis identifies shared regions and creates an efficient build plan. Modular enzymatic synthesis turns that plan into expression-ready DNA constructs in less than 24 hours.
Optimize The Sequence
Gibson SOLA software checks and optimizes designs for build success, efficiency, & expression. A custom build file provides the necessary pooling instructions.
Build On-Demand
Pre-qualified, universal building blocks and enzymatic reagents, enable modular synthesis of DNA. Expression-ready DNA is synthesized in less than 24 hours.
Synthesize Efficiently
Modular assembly enables Intelligent Synthesis. Conserved regions within a panel are only synthesized once, reducing cost and increasing throughput.
Minimize Hands-On Time
Run on standard lab automation equipment you already have. Validated scripts enable hands-free, fully-autonomous workflows resulting in expression-ready DNA.
CONNECTING AI TO BIOLOGY
Your AI predicts. Our AI designs the build.
Connect protein prediction to DNA production. Our AI-powered design software will assess sequence complexity and balance buildability, expression, and synthesis efficiency, then translate your design into custom build instructions - all fully integrated into your AI infrastructure.
01
AI-predicted sequences
Bring protein or nucleotide sequences from any AI design tool.
protein
Nucleotide
02
Analyze
Complexity
Every sequence is scored for synthesis and assembly risk, so problems surface before anything is built.
Restriction Sites
GC Balance
Repeats
Homopolymers
03
Optimize The Design
Codon optimization removes the blockers it finds while tuning for expression & efficient synthesis - resulting in most sequences being buildable.
E. coli
CHO
Human
04
Generate Build Instructions
The Gibson SOLA Design software converts your sequence panel into custom build instructions for your lab's automation.
Automation-ready files
SOLA 3 run
THE BUILD PROCESS
Create custom SOLA-mer pools
Made-to-stock building blocks are rapidly pooled using an acoustic liquid handler as indicated by the custom build file.
Assemble SOLA-mers into short subunits
A simple 2-stage process enzymatically assembles the building blocks into short, intermediate subunits.
Assemble subunits into full-length genes
Subunits are re-arrayed, using an Intelligent Synthesis algorithm to enable a final round of assembly.
Attach expression components
Expression elements - such as promoters, regulatory elements, and signal sequences - can be added at this stage to assemble a full-length linear expression cassette (LEC).
Expression-ready DNA
This process results in an expression-ready LEC in 1 day starting from a digital sequence and stock reagents. This same approach can be used to create a plasmid for downstream cloning workflows.
INTELLIGENT SYNTHESIS
Synthesize the difference - not the entire construct
Your designs share more than you think. Gibson SOLA identifies common DNA sequences within your designed panel and creates a coordinated synthesis plan - building shared regions once and combining them with unique regions to produce each construct. By eliminating redundancy, Intelligent Synthesis makes better use of reagents and build capacity, lowering the cost per construct and helping you explore more designs.
THE TECHNOLOGY STACK
Three components - one Build Engine
Software, reagents and automation are designed to work together so that predicted sequences can become biological DNA.
Gibson SOLA Design Software
The Gibson SOLA design software uses AI to evaluate and optimize sequences for build success, build efficiency, and expression. It provides the necessary output files to initiate an automated synthesis process. The software is designed to integrate into your existing agentic AI infrastructure allowing you to go from prediction to build seamlessly.
Gibson SOLA Reagent Kit
Pre-qualified, universal reagents enable on-demand, fully-autonomous synthesis. The reagents are provided in bulk format to ensure that you can load them quickly and execute a run without multiple touchpoints. The reagents are stable so that you can stock up to keep your lab running smoothly.
Implementation Expertise
The Gibson SOLA platform is designed to run on your standard lab automation equipment using validated workflows that build expression-ready DNA at virtually any throughput in 24 hours. We partner with you to design a fully automated solution tailored to your infrastructure and goals.
Your AI predicts what's next. Build it today.
About Telesis Bio
Telesis Bio enables researchers to eliminate outsourcing delays and boost productivity by enabling rapid, on-site synthesis of high-fidelity DNA and mRNA with its Gibson SOLA® platform. Designed to integrate with standard lab automation, Gibson SOLA gives scientists full control over build timelines and IP. From antibodies to cell therapies, innovators across biotech and pharma use Telesis Bio to accelerate development in synthetic biology and therapeutic discovery.
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