Gibson SOLA Platform
Generate uniquely high-quality DNA
Remove cloning from gene expression workflows
What do you want to build?
The Gibson SOLA Platform is a 'digital to biological converter' that is transforming biological research by empowering scientists to create the DNA they need, when they need it.
Traditional chemical synthesis produces DNA one base at a time, accumulating errors over many cycles as the DNA grows longer. The Gibson SOLA Platform uses a different hybridization-based synthesis that enriches for the correct molecule at each cycle and produces uniquely high-quality DNA, resulting in over 90% full-length product.
- Uniquely high-quality: DNA with >90% full-length sequences comes right off of the synthesizer, removing the need for multiple rounds of downstream purification (ex: HPLC).
- Reduce costs: Stop paying for dedicated HPLC columns that are required by traditional GMP-grade synthesis.
- Make what you need: Generate DNA or mRNA with secondary structures and/or high GC content.
Why is DNA quality important?
- Scale as needed: Generate 10's to 100's of kb of >90% full-length DNA or mRNA.
- Budget wisely: Stop paying for required purification upgrades from service providers.
- Be efficient: Remove cloning from your protein expression workflow.
DNA is assembled in blocks rather than one base at a time, resulting in uniquely high-quality DNA.
How does high-quality DNA eliminate cloning from protein expression workflows?
The high fidelity of the Gibson SOLA Platform enables cloning-free workflows for expression. By adding regulatory elements directly to the sequence during synthesis, you can transfect linear expression templates directly off the synthesis line in about a week. In addition, if your workflow can be supported by cell-free protein synthesis systems, timelines from sequence to protein can be as short as three days. This removes the need for E. coli as a host, streamlining the entire workflow without sacrificing fidelity.
Cellular and cell-free expression can now be completed in days.
What is the fidelity of E.coli-less DNA?
As measured by PacBio® HiFi NGS, 90-99% of sequences were error-free directly off of the synthesis platform. No further purification was performed.
What could you build with uniquely high-quality DNA?
Determine how Gibson SOLA could empower your team with a personalized 1:1 consultation
Meet with our experts to determine how Gibson SOLA could help you build what you want, when you want it.
1:1 Consultations available to determine how Gibson SOLA could enable your team.