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Harnessing the power of synthetic biology to combat COVID-19

Given the COVID-19 global healthcare emergency, accelerating the pace of innovation and developing tools to combat the spread of COVID-19 is paramount. The scientific community is operating at its creative best to identify and advance solutions for prevention, detection, and treatment. The BioXp® system is the ideal platform to enable researchers around the world to rapidly synthesize SARS-CoV-2 genome parts, making them readily available for developing vaccines, diagnostics, and therapeutics.

In this application note, we describe the on-demand production of the entire genome of SARS-CoV-2. Genome parts were designed and synthesized using the BioXp® system. We also describe the joining of these parts to assemble the full-length genome of SARS-CoV-2 as a bacterial artificial chromosome (BAC) in E. coli. Given the number of genome variants of SARS-CoV-2 that have been identified thus far, it may become imperative to incorporate them into the vaccine, therapeutic, and diagnostic development pipelines quickly. The BioXp® system accelerates this pipeline by enabling rapid synthesis of up to 32 individual, variant genome parts in a single, overnight run of the instrument.

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Are you working hard in this fight? We’re in your corner.

Telesis Bio recognizes that there is no time to waste in combating the SARS-CoV-2. We support the fight by co-funding BioXp® systems for front-line researchers conducting research and development on SARS-CoV-2. The BioXp® system is the world’s first automated solution for creating DNA constructs, providing researchers with the ability to design, build, and amplify synthetic de novo gene constructs overnight. It has been used to develop vaccines and therapeutics against pandemic virus outbreaks like the H7N9 bird flu. With the BioXp® system, you’ll quickly have the constructs needed to fight the coronavirus, and whatever might be next.

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